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Toluene is also called as toluol, is an aromatic hydrocarbon. Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Reaction of Isocyanate with Urea: Urea may form from the TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. The reaction rate of TDI with water at temperatures less than 500C is very low. The Support section provides tools and practical guidance to companies which have responsibilities under the EU chemicals legislation. 1989]. This reaction is very important in PU foam production. REACH registered substance data was upgraded on 9th November. Application p-Toluenesulfonyl isocyanate has been used as : • derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. Pre-Registration process . * Toluene-2,4-Diisocyanate reacts with WATER releasing Carbon Dioxide gasand HEAT which may cause containers to rupture. Isocyanates also react with amines to give ureas: R … Manipulation 6 29 30. The reaction of PTSI with water introduced from pigments and solvents in the paint formulation generates carbon dioxide and solu‐ ble inert chemical products. ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. Explosion limits For 2,4 TDI Concentration (% v/v) lower 0.9% upper 9.5% Boiling point At 760mmHg 251° C At 10mmHg 120° C for 2,4-TDI 121° C for commercial mixture Density (g/cm Brief Profile REACH registered substance factsheets C&L Inventory Biocidal active substance factsheets PACT tool Regulatory Obligations . Regulatory process names 2 Other names 1 Other identifiers 3 . The blowing reaction (3), of isocyanates with water, results in urea formation and carbon dioxide gas release. Addition of base to water increase the rate of reaction with TDI, since the base abstracts the proton forming hydroxyl. c) continuously mixing the mixture containing toluene-diisocyanate and the distillation residue of toluene-diisocyanate with water, at a temperature of less than 230° C. under an absolute pressure of less than 30 bar, and allowing said mixture to react under the same conditions (i.e. Because of the high reactivity of TDI /toluene diisocyanate/ waste waters contain only reaction products from the reaction with water. Glutathione has previously been identified as a reaction target for toluene diisocyanate (TDI) in vitro and in vivo, and has been suggested to contribute to toxic and allergic reactions to exposure. We have investigated the ability of the products of the reaction between toluene diisocyanate (TDI) and water to contract bronchial smooth muscle. Recommendable methods: Incineration, alkaline hydrolysis, discharge to sewer. Help Key datasets. Toluene diisocyanate, oligomeric reaction products with water . This reaction is exploited in tandem with the production of polyurethane to give polyurethane foams. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. Potential explosion if stored in polyethylene containers due to … PMDI is a dark reddish brown liquid with an indefinite melting point around 0 °C and a vapour pressure of <1 mPa at 20 °C. Toluene diisocyanate is miscible with many organic solvents, but it is almost insoluble in water. Reaction with water to form Carbon Dioxide [Merck 11th ed. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. The carbon dioxide functions as a blowing agent. As the temperature increases the reaction becomes more vigorous, but the vapours increases. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. It covers their hazardous properties, classification and labelling, and information on how to use them safely. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Toluene diisocyanate - 1 Toluene diisocyanate (1,3-Diisocyanatomethylbenzene, 2,4- and 2,6-Toluene diisocyanate, ... atmosphere by reaction with photochemically-produced hydroxyl radicals with an estimated half-life of 2.7 days for the mixed isomers, 1.7 days for 2,4-TDI, and 2.5 days . The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1: Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … * n-octanol/water distribution coefficient. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Des renseignements inscrits sur l'étiquette et la fiche de données de sécurité avant manipuler... 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