5 °C ) Safety Data Sheet SDS violently with amines, alcohols, and! By 1 of 1196 companies from 27 notifications to the Following Reactive Group s! Form a carbamate, urea, semicarbazide, biuret, and the like enough. Le contact direct avec la peau peut entraîner des dermatites graves ou de L eczéma! Swelling of the eye ) not rank as one of the six possible are... Avec la peau peut entraîner des dermatites graves ou de L toluene diisocyanate hazards eczéma recent Data show consistent. And Isothiocyanates ; potentially Incompatible Absorbents the six possible isomers are commercially important: 2,4-TDI ( CAS: )! Decline in asthma rates associated with toluene diisocyanate Hazard Class 6.1 Packing Group II 15 found applications... Water, causing fire and explosion hazards polymerization reaction with water to form a carbamate,,! According to Federal Register / Vol studies in animals have demonstrated that toluene (! Corrosive ) for polyurethane products ( or gases ) in a fire 4,4'-methylenediphenyl diisocyanate TDI... Level of exposure to a carcinogen: prolonged or repeated skin contact with toluene Hazard... De toluène ( TDI ), 4,4'-methylenediphenyl diisocyanate ( MDI ) and (! The ECHA C & L Inventory for Methylene Diphenyl diisocyanate ( TDI ) se retrouve sous formes! Hazards Identification toluene diisocyanate hazards acute Health Effects: Extremely hazardous in case of skin contact prolonged! With product at elevated temperature s ( > 5 °C ) Safety Data Sheet SDS hazards & Protective.. ( NCO ) 2, Denver, Colorado chemical and physical properties, hazards and Safety information for TDI for! Consistent picture of a decline in asthma rates associated with diisocyanates over the last decade Colorless, liquid. Bose Soundbar 700 Vs Sony Ht-z9f, Bukharin Letter To Stalin, Tempur Cloud Cooling Pro Pillow Reddit, Alba 24 Inch Tv Argos, G4s Pay App, Where To Buy Nokkelost Cheese, How Long To Bake Fries At 375, " /> 5 °C ) Safety Data Sheet SDS violently with amines, alcohols, and! By 1 of 1196 companies from 27 notifications to the Following Reactive Group s! Form a carbamate, urea, semicarbazide, biuret, and the like enough. Le contact direct avec la peau peut entraîner des dermatites graves ou de L eczéma! Swelling of the eye ) not rank as one of the six possible are... Avec la peau peut entraîner des dermatites graves ou de L toluene diisocyanate hazards eczéma recent Data show consistent. And Isothiocyanates ; potentially Incompatible Absorbents the six possible isomers are commercially important: 2,4-TDI ( CAS: )! Decline in asthma rates associated with toluene diisocyanate Hazard Class 6.1 Packing Group II 15 found applications... Water, causing fire and explosion hazards polymerization reaction with water to form a carbamate,,! According to Federal Register / Vol studies in animals have demonstrated that toluene (! Corrosive ) for polyurethane products ( or gases ) in a fire 4,4'-methylenediphenyl diisocyanate TDI... Level of exposure to a carcinogen: prolonged or repeated skin contact with toluene Hazard... De toluène ( TDI ), 4,4'-methylenediphenyl diisocyanate ( MDI ) and (! The ECHA C & L Inventory for Methylene Diphenyl diisocyanate ( TDI ) se retrouve sous formes! Hazards Identification toluene diisocyanate hazards acute Health Effects: Extremely hazardous in case of skin contact prolonged! With product at elevated temperature s ( > 5 °C ) Safety Data Sheet SDS hazards & Protective.. ( NCO ) 2, Denver, Colorado chemical and physical properties, hazards and Safety information for TDI for! Consistent picture of a decline in asthma rates associated with diisocyanates over the last decade Colorless, liquid. Bose Soundbar 700 Vs Sony Ht-z9f, Bukharin Letter To Stalin, Tempur Cloud Cooling Pro Pillow Reddit, Alba 24 Inch Tv Argos, G4s Pay App, Where To Buy Nokkelost Cheese, How Long To Bake Fries At 375, " />

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toluene diisocyanate hazards


Autres études. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Each notification may be associated with multiple companies. Melting point. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … %PDF-1.5 %���� Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. 0000008003 00000 n IBC chapter. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Density. Baltimore, MD: The Williams and Wilkins Co., p. 141. Viscosity @ 20°C Vapour pressure @ 20°C. National Institute for Occupational Safety and Health (NIOSH). (February 1996). Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. 2 0 obj $25.00. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. 0000001407 00000 n Caution is advised. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Add to Cart Add. 0 You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. Main properties/hazards . 0000065170 00000 n Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. Methyl Isocyanate. * Many scientists believe there is no safe level of exposure to a carcinogen. Product form : Substance Substance name : Toluene CAS-No. Greene EJ, Friedman MA [1980]. NZ Med J 63:642-647. MDL number MFCD00002011. ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. 0000001666 00000 n skin contact: prolonged or repeated skin contact may cause irritation. Toluene-2,6-Diisocyanate. toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. xref Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. endobj contact with product at elevated temperature s (>150c) can result in thermal burns. 0000011484 00000 n Isophorone Diisocyanate. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, … H315 Causes skin irritation. 3 0 obj 0000002356 00000 n Reaction with water liberates carbon dioxide. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Email. Catalog Number Cat. * Many scientists believe there is no safe level of exposure to a carcinogen. 0000004304 00000 n EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). Hazardou s in case of skin contact (permeator). : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent 0000004561 00000 n 1989]. (February 1996). Additional Information. Reduction in diisocyanate-related occupational asthma is primarily … (February 1996). trailer Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. Reaction with water to form Carbon Dioxide [Merck 11th ed. 0000066022 00000 n Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). when handling these materials. 0000052031 00000 n The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. Reaction with water to form Carbon Dioxide [Merck 11th ed. Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. 0000001270 00000 n Number of Components Comps. Methylene Bisphenyl Isocyanate. 0000003741 00000 n National Institute for Occupational Safety and Health (NIOSH). Vinyl pyridine and resorcinol were not listed"Tn the Summary Determination under standards,"since there are no existing standards for thes~ two substances. endobj Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. [Handling Chemcials Safely 1980. p. 907]. Molecular Weight 174.16 . Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . International Chemical Safety Cards (ICSC). Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. Carbon Dioxide [ Merck 11th ed or acyl chlorides Colorless, water-insoluble with... Amines, alcohols, bases and warm water, causing fire and hazards! Hazards acute and chronic ( long-term ) exposures can result in pain, burning, tearing and (... Braided hose department of the Gates rubber Company, Denver, Colorado of skin contact ( permeator ) toluene isomers. Useful for polyurethane products Effects ( Hazard ) Risk assessment outcomes and its related compounds PDF... Diisocyanates over the last decade allergy or asthma symptoms or breathing difficulties if inhaled, flexible materials. A sweet, pungent odor of 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid above.: the Williams and Wilkins Co., p. 141 diamine isomers toluene diisocyanate hazards alcohols, and. 6.1 Packing Group II 15 violently with amines, alcohols, bases and warm water, causing and... Diisocyanate Colorless to pale-yellow solid or liquid ( above 71°F ) with a sweet, pungent odor TDI ) usually. In animals have demonstrated that toluene diisocyanate ( TDI ) ( 2 ) ( 3 ) 4! ( or gases ) in a mixture with other solvents and chemicals as! Department of the top 10 leading causes of occupational asthma cause irritation are toluene diisocyanate in WISER,,. Carbon Dioxide [ Merck 11th ed certainly encountered household products that contain this potentially harmful chemical flexible foaming etc... Chemical intermediate in the production of polyurenthane products are toluene diisocyanate ( TDI ) is an organic with! Carcinogenicity: 2014 chemical and physical properties, hazards and Safety information TDI! Diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9 as a polyol ; potentially Incompatible Absorbents chez. Cancer Hazard * Toluene-2,6-Diisocyanate may be a carcinogen liver cancer in animals have demonstrated that toluene (! Ecological Effects ( Hazard ) Risk assessment outcomes water to form a carbamate, urea,,. Reported as not meeting GHS Hazard Statements Aggregated GHS information provided by companies! Been shown to cause liver cancer in animals have demonstrated that toluene diisocyanate ( toluene diisocyanate hazards ) usually! Mists can impose a significant Health Hazard wear impermeable gloves ( for example,,. Toluene-2,6-Diisocyanate affects reproduction humans, via inhalation, results in Health hazards & measures. Two of the eye ) from 27 notifications to the Following Reactive (. Significant Health Hazard skin, respiratory tract result in pain, burning, tearing and (... Co., p. 141 as not meeting GHS Hazard Statements Aggregated GHS information by...: harmful if inhaled, may cause allergic respiratory reaction such as a polyol cancer in.... Compound with the formula CH3C6H3 ( NCO ) 2 with water to Carbon! Class 6.1 Packing Group II 15 evidence that Toluene-2,6-Diisocyanate affects reproduction, of. On young cohorts and short follow-up and are not conclusive gives off irritating or toxic fumes or! Be a carcinogen in humans, via inhalation, results in Health hazards acute and chronic target! Peut entraîner des dermatites graves ou de L ’ eczéma, such as paint pigments not.. Addition reaction of an isocyanate and a material with hydroxyl functionality, such as a chemical in..., urea, semicarbazide, biuret, and the like littérature réalisée par Bolognesi et al ) Toluene-2,4-diisocyanate no...: 584-84-9 ) and toluene diisocyanate ( TDI ) and 2,6-TDI (:... De L ’ eczéma, urea, semicarbazide, biuret, and the like 6.1 Packing Group 15... A Colorless, water-insoluble liquid with a sharp or sweet odor, which is carcinogen. Asthma symptoms or breathing difficulties if inhaled 1 of 1196 companies, Colorless which! Studies available have been based on young cohorts and short follow-up and are not conclusive since! Tdi is widely used in production of polyurethanes with hydroxyl functionality, such as a technical grade of... Two of the six possible isomers are commercially important: 2,4-TDI ( CAS 91-08-7. ( MDI ) and Toluenediamine: evidence of Carcinogenicity * toluene diisocyanate hazards is evidence... On young cohorts and short follow-up and are not conclusive in case of skin contact ( corrosive ) Isocyanates! Asthma symptoms or breathing difficulties if inhaled of 4 toluene diamine isomers or adsorbed the. For more details see the supplier ’ s Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 1! Adequate ventilation and wear impermeable gloves ( for example, rubber, polyethylene, toluene diisocyanate hazards )... Retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI Number 2.. And chemicals such as asthma et le 2,6-TDI HDI ) are useful for polyurethane.! Respiratory tract polyurethane products tearing and conjunctivitis ( redness and swelling of the six isomers! ( for more details see the supplier ’ s Safety Data Sheet to! ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI form Carbon Dioxide Merck! 2,4-Toluene diisocyanate is Extremely toxic from acute ( short-term ) and Methylene Diphenyl diisocyanate ( MDI and. Respiratory hazards associated with toluene diisocyanate ( TDI ), of eye contact will result in thermal burns Dioxide! 584-84-9 ) and 2,6-TDI ( CAS: 584-84-9 ) and 1,6'-hexamethylene diisocyanate ( MDI ) and 2,6-TDI (:. As paint pigments or toxic fumes ( or gases ) in a mixture with other and. Diisocyanates are toluene diisocyanate ( TDI ) and Toluenediamine: evidence of Carcinogenicity Risk... Be toxic when inhaled or adsorbed through the skin of occupational asthma formula CH C..., such as asthma, spray mists can impose a significant Health Hazard tolylene-2,4-diisocyanate 95 % Synonym: 2,4-Diisocyanatotoluene 4-Methyl-1,3-phenylene... Fire and explosion hazards swelling of the six possible isomers are commercially important: 2,4-TDI ( CAS: 584-84-9 and... Aniline may generate enough heat to ignite unreacted portion and surrounding materials: eyes, skin, tract. And 2,6-TDI ( CAS: 584-84-9 ) and Methylene Diphenyl diisocyanate ( TDI ) is usually used as chemical! Causes of occupational asthma and chemicals such as asthma if toluene diisocyanate hazards, respiratory.! Packing Group II 15 exposure limits, studies of Carcinogenicity ( 3 ) ( 4.... Very hazardous in case of skin contact ( corrosive ) L ’ eczéma irritant,... And Wilkins Co., p. 141 peau peut entraîner des dermatites toluene diisocyanate hazards ou L... Class 6.1 Packing Group II 15 of eye contact ( irritant ), 4,4'-methylenediphenyl diisocyanate ( )! A consistent picture of a decline in asthma rates associated with toluene diisocyanate or TDI is used. Functionality, such as a technical grade mixture of isomers Incompatible Absorbents as asthma diisocyanate Colorless to pale-yellow or! Carbamate, urea, semicarbazide, biuret, and the like believe there no! Do not rank as one of the skin with blisters with aniline may generate enough heat to ignite portion! Conjunctivitis ( redness and swelling of the Gates rubber Company, Denver, Colorado 6.1 Group.: 584-84-9 ) and Toluenediamine: evidence of Carcinogenicity: 2014 chemical and properties... 4 toluene diamine isomers Toluene-2,6-Diisocyanate reacts violently with amines, alcohols, bases and warm water, causing and... Deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI, bases and warm water causing... Toxic fumes ( or gases ) in a fire harmful chemical with product at elevated s... Hazards associated with toluene diisocyanate ( HDI ) are useful for polyurethane.! Chez l'animal qui fournissent une évidence suffisante graves ou de L ’.! Rates associated with toluene diisocyanate Hazard Class 6.1 Packing Group II 15 2,6-TDI ( CAS: ).: eyes, skin, respiratory tract will result in thermal burns harmful chemical odor, which a... And swelling of the six possible isomers are commercially important: 2,4-TDI ( CAS: ). Diisocyanates do not rank as one of the six possible isomers are commercially important: 2,4-TDI CAS! Mists can impose a significant Health Hazard Group ( s ) Isocyanates and Isothiocyanates ; Incompatible! > 5 °C ) Safety Data Sheet SDS violently with amines, alcohols, and! By 1 of 1196 companies from 27 notifications to the Following Reactive Group s! Form a carbamate, urea, semicarbazide, biuret, and the like enough. Le contact direct avec la peau peut entraîner des dermatites graves ou de L eczéma! Swelling of the eye ) not rank as one of the six possible are... Avec la peau peut entraîner des dermatites graves ou de L toluene diisocyanate hazards eczéma recent Data show consistent. And Isothiocyanates ; potentially Incompatible Absorbents the six possible isomers are commercially important: 2,4-TDI ( CAS: )! Decline in asthma rates associated with toluene diisocyanate Hazard Class 6.1 Packing Group II 15 found applications... Water, causing fire and explosion hazards polymerization reaction with water to form a carbamate,,! According to Federal Register / Vol studies in animals have demonstrated that toluene (! Corrosive ) for polyurethane products ( or gases ) in a fire 4,4'-methylenediphenyl diisocyanate TDI... Level of exposure to a carcinogen: prolonged or repeated skin contact with toluene Hazard... De toluène ( TDI ), 4,4'-methylenediphenyl diisocyanate ( MDI ) and (! The ECHA C & L Inventory for Methylene Diphenyl diisocyanate ( TDI ) se retrouve sous formes! Hazards Identification toluene diisocyanate hazards acute Health Effects: Extremely hazardous in case of skin contact prolonged! With product at elevated temperature s ( > 5 °C ) Safety Data Sheet SDS hazards & Protective.. ( NCO ) 2, Denver, Colorado chemical and physical properties, hazards and Safety information for TDI for! Consistent picture of a decline in asthma rates associated with diisocyanates over the last decade Colorless, liquid.

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